Today, water pollution poses potential risks to human health and the environment. Recent research activities have focused on advanced oxidation processes (AOPs) as innovative technologies for water purification. Cerium oxide (CeO₂) is one of the most abundant rare earth oxides, which, when combined with other metals, creates an active surface and enhances photocatalytic properties. This study investigated the antibacterial properties and photocatalytic activity of cerium oxide nanoparticles combined with the semiconductors nickel and copper in the removal of organic pollutants (Amoxicillin) and antibacterial. The results showed that these nanocomposites have significant antibacterial properties at high concentrations. The optimal amount of the nanocomposite was found to be 0.7 mg/L, with a pH of 3 being the optimal condition for this experiment. Additionally, the optimal concentration of the pollutant was 5mg/L, which, in the presence of the nanocomposites CuCo₂O₄/CeO₂ and NiCo₂O₄/CeO₂, successfully removed 81% and 78% of the organic pollutant, respectively, under UV-A light exposure. The results of this study indicate that the synthesis of CuCo₂O₄/CeO₂ and NiCo₂O₄/CeO₂ nanoparticles serves as an effective antibacterial and highly photocatalytic material that can be used for the removal of organic pollutants and antibacterial. Considering the frequency of presence of organic pollutants and pathogens in the water environment, this research aims to strengthen CeO₂ with different morphologies by metals such as Cu and Ni so that they can act as recombination centers and increase its photocatalytic properties.